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After that, the solid gold shell was scratched into solid AuNS (HAuNS), and to create HAuNS@PEG-bio, it was further altered using biotin-PEG-SH (PEG-bio)

That accumulation occurs thanks to 2 pathways: the first is the poor or null elimination of that metal by the biliary tract, which causes an elevated serum concentration, and the second is portal hypertension and the creation of collateral circulation, favored by the disruption of the blood-brain barrier, as the pathway of propagation to the brain

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Tyrosinase plays an important role in the formation of melanin in hair